Vaccine-Derived Polioviruses and the Endgame Strategy for Global Polio Eradication

A review of vaccine-derived polioviruses and the endgame strategy for global polio eradication. Both papers cite it for strains derived from the oral vaccine that can regain virulence, so eradication requires withdrawing the vaccine itself. The open substrate is the datasphere's analog, and since it cannot be withdrawn, lineages can re-originate, one support of the escape ratchet (C1).

Cited in

both papers (Flagship: Three conjectures; Companion §7)

Used for

C1Prediction 5C1 (re-origination); prediction 5

Strand

Domestication, invasion & eradication · Eradication, control & irreversibility

Cite

@article{kew2005vaccine,
  title = {Vaccine-Derived Polioviruses and the Endgame Strategy for Global Polio Eradication},
  author = {Olen M. Kew and Roland W. Sutter and Esther M. de Gourville and Walter R. Dowdle and Mark A. Pallansch},
  year = {2005},
  journal = {Annual Review of Microbiology},
  doi = {10.1146/annurev.micro.58.030603.123625},
}